BCL10 antibody (AA 122-168)

Catalog No. ABIN379257

The Mouse Monoclonal anti-BCL10 antibody has been validated for . It is suitable to detect BCL10 in samples from Human.

Quick Overview for BCL10 antibody (AA 122-168) (ABIN379257)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Please inquire

Clone: 151

Product Details anti-BCL10 Antibody

Binding Specificity: AA 122-168

Specificity: Monoclonal Anti-Bcl-10 reacts specifically with human Bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human Bcl-10 Molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of Bcl-10 expression is also demonstrated to be involved in cellular oncogenesis.

Purification: Protein G purified

Immunogen: Human recombinant Bcl-10.

Isotype: IgG1

Application Details

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Buffer contains: 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: BCL10 / BCL-10

Background: Name/Gene ID: BCL10
Family: Apoptosis

Synonyms: BCL10, Bcl-10, B-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, CARMEN, CARD-like apoptotic protein, CCARMEN, C-E10, CIPER, Cellular-E10, HCLAP, Cellular homolog of vCARMEN, CLAP, ME10

Gene ID: 8915

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins